Overview of the Research Goals of the Yarema Laboratory

References

21. Campbell, C.T., Sampathkumar, S.-G., Weier, C. & Yarema, K.J. Metabolic oligosaccharide engineering: perspectives, applications, and future directions. Mol. Biosys. 3 , 187-194 (2007).

22. Aich, U. & Yarema, K.J. in Glycosciences, Edn. 2. (eds. B. Fraser-Reid, K. Tatsuta & J. Thiem) 2136-2190 (Springer-Verlag Berlin Heidelberg; 2008).

23. Wang, Z., Du, J., Che, P.-L., Meledeo, M.A. & Yarema, K.J. Hexosamine analogs: From metabolic glycoengineering to drug discovery. Curr. Opin. Chem. Biol. 13 , 565-572 (2009).

24. Du, J., Meledeo, M.A., Wang, Z., Khanna, H.S., Paruchuri, V.D. & Yarema, K.J. Metabolic glycoengineering: Sialic acid and beyond. Glycobiology 19 , 1382-1401 (2009).

25. Du, J. & Yarema, K.J. Carbohydrate engineered cells for regenerative medicine. Adv. Drug Deliv. Rev. 62 , 271-282 (2010).

26. Elmouelhi, N., Aich, U., Paruchuri, V.D.P., Meledeo, M.A., Campbell, C.T., Wang, J.J., Srinivas, R., Khanna, H.S. & Yarema, K.J. Hexosamine template. A platform for modulating gene expression and for sugar-based drug discovery. J. Med. Chem. 52 , 2515-2530 (2009).

27. Aich, U., Meledeo, M.A., Sampathkumar, S.-G., Fu, J., Jones, M.B., Weier, C.A., Chung, S.Y., Tang, B.C., Yang, M., Hanes, J. & Yarema, K.J. Development of delivery methods for carbohydrate-based drugs: controlled release of biologically-active short chain fatty acid-hexosamine analogs Glycoconjug. J. 27 , 445-459 (2010).

28. Hinderlich, S., Salama, I., Eisenberg, I., Potikha, T., Mantey, L.R., Yarema, K.J., Horstkorte, R., Argov, Z., Sadeh, M., Reutter, W. & Mitrani-Rosenbaum, S. The homozygous M712T mutation of UDP-N-acetylglucosamine 2-epimerase / N -acetylmannosamine kinase results in reduced enzyme activities but not in altered overall cellular sialylation in hereditary inclusion body myopathy. FEBS Lett. 566 , 105-109 (2004).

29. Salama, I., Hinderlich, S., Shlomai, Z., Eisenberg, I., Krause, S., Yarema, K.J., Argov, Z., Lochmuller, H., Reutter, W., Dabby, R., Sadeh, M., Ben-Bassat, H. & Mitrani-Rosenbaum, S. No overall hyposialylation in hereditary inclusion body myopathy myoblasts carrying the homozygous M712T GNE mutation. Biochem. Biophys. Res. Commun. 328 , 221-226 (2005).

30. Galeano, B., Klootwijk, R., Manoli, I., Sun, M., Ciccone, C., Darvish, D., Starost, M.F., Zerfas, P.M., Hoffmann, V.J., Hoogstraten-Miller, S., Krasnewich, D.M., Gahl, W.A. & Huizing, M. Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine. J. Clin. Invest. 117 , 1585-1594 (2007).

31. Varghese, S., Theprungsirikul, P., Sahani, S., Hwang, N., Yarema, K.J. & Elisseeff, J.H. Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression. Osteoarthritis Cartilage 15 , 59-68 (2007).