Kevin J. Yarema

Associate Professor of Biomedical Engineering

Laboratory of Cell and Carbohydrate Engineering

Contact Information:

Office: (410) 614-6835
Fax:    (410) 614-6840
Lab:    (410) 502-1459
Email:  kyarema1 AT jhu.edu


Ms. Diana Z. Reynolds (Lab Administrator)

Email:   diana at jhu.edu
Phone: (410) 614-6836

 

Our laboratory's research has the following four goals

1. Develop sugar analogs into viable and versatile drug candidates

2. Apply metabolic glycoengineering to tissue engineering and stem cell research

3. Use non-invasive magnetic stimuli to probe the effects of glycoengineering (and also to treat neurological disorders).

4. Extend our sugar-based drug candidates into animal models and the clinic

Additional information about each area can be found of the research page

 

Selected Publications

1. Campbell CT, Sampathkumar S-G, Weier C, & Yarema KJ. Metabolic oligosaccharide engineering: perspectives, applications, and future directions. Mol Biosyst. 2007; 3:187-194.

2. Sampathkumar S-G, Li AV, Jones MB, Sun Z, & Yarema KJ. Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology. Nat Chem Biol. 2006; 2:149-152.

3. Campbell CT, Aich U, Weier CA, Wang JJ, Choi SS, Wen MM, Maisel K, Sampathkumar S-G, & Yarema KJ. Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogs inhibits the mobility of metastatic MDA-MB-231 breast cancer cell. J Med Chem. 2008; 51:8135�8147.

4. Elmouelhi N, Aich U, Paruchuri VDP, Meledeo MA, Campbell CT, Wang JJ, Srinivas R, Khanna HS, & Yarema KJ. Hexosamine template. A platform for modulating gene expression and for sugar-based drug discovery. J Med Chem. 2009; 52:2515-2530.

5. Krambeck FJ, Bennun SV, Narang S, Choi SS, Yarema KJ, & Betenbaugh MJ. A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data. Glycobiology. 2009 19:1163-1175.

6. Wang Z, Sarje A, Che P-L, & Yarema KJ. Moderate strength (0.23-0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells. BMC Genomics. 2009; 10:356.

7. Du, J. Che, P.-L., Aich, U., Tan, E., Kim, H.J., Sampathkumar, S.-G., & Yarema, K.J. (2011) Deciphering glycan linkages involved in Jurkat cell interactions with gold-coated nanofibers via sugar-displayed thiols. Bioorganic and Medicinal Chemistry Letters, 21, 4980-4984. PMCID: In progress


8. Almaraz, R.T., Aich, U., Khanna, H.S., Tan, E., Bhattacharya, R., Shah, S. & Yarema, K.J. (2011) Metabolic oligosaccharide engineering with N-acyl functionalized ManNAc analogues: cytotoxicity, metabolic flux, and glycan-display considerations. Biotechnology & Bioengineering (In press October, 2011).