Our laboratory uses a multifaceted ‘glycoengineering’ approach that exploits the tools of chemical biology; synthetic chemistry; cellular biology and genetics; and materials science to study and manipulated glycosylation. Our overall goals are to better understand human disease while forwarding carbohydrate-based therapies by:
1. Developing glycoengineering tools and technology.
2. Applying metabolic glycoengineering (MGE) to treat disease (e.g., cancer and osteoarthritis).
3. Applying MGE to stem cell biology and regenerative medicine.
4. Developing carbohydrate-based and targeting drugs that modulate cancer cell metabolism (coming soon).