The Yarema Laboratory takes a multifaceted approach to study and manipulate glycosylation, the addition of complex sugars to the cell surface. Our goals are to better understand human disease while forwarding carbohydrate-based therapies. By controlling the type and level of glycosylation through “metabolic glycoengineering,” we are learning how glycosylation affects a cell’s fate and environmental interactions.
- Develop sugar analogs into viable and versatile drug candidates
- Apply metabolic glycoengineering to cellular, tissue, and stem cell engineering
- Probe the effects of glycoengineering therapeutic candidates
- Extend our sugar-based drug candidates into animal models and the clinic