Our Research

The Yarema Laboratory takes a multifaceted approach to study and manipulate glycosylation, the addition of complex sugars to the cell surface. Our goals are to better understand human disease while forwarding carbohydrate-based therapies. By controlling the type and level of glycosylation through “metabolic glycoengineering,” we are learning how glycosylation affects a cell’s fate and environmental interactions.

Four Goals

  1. Develop sugar analogs into viable and versatile drug candidates
  2. Apply metabolic glycoengineering to cellular, tissue, and stem cell engineering
  3. Probe the effects of glycoengineering therapeutic candidates
  4. Extend our sugar-based drug candidates into animal models and the clinic