Research Publications

Ludwig, S.D., Bernstein, A.J., Agatemor, C., Dammen-Brower, K., Ruffolo, J., Rosas, J.M., Post, J.D., Cole, R.N., Yarema, K.J., & Spangler, J.B. (2022) A versatile design platform for glycoengineering therapeutic antibodies. mAbs, 14 (doi: 10.1080/19420862.2022.2095604)

Du., J., Liu, X.,, Yarema, K.J., & Jia. X. (2022) Glycoengineering human neural stem cells (hNSCs) for adhesion improvement using a novel thiol-modified N-acetylmannosamine (ManNAc) analog. Biomaterials Advances134, article 112675 (doi: 10.1016/j.msec.2022.112675Pubmed

Du, J., Agatemor, C., Saeui, C., Bhattacharya, R., Jia, X., & Yarema, K.J. (2021) Glycoengineering human neural and adipose stem cells with novel thiol-modified N-acetylmannosamine (ManNAc) analogs. Cells10, article 377 (doi: 10.3390/cells10020377Pubmed

Stabach, P.R., Zimmerman, K., Adame, A., Kavanagh, D., Saeui, C.T., Agatemor, C., Gray, S., Cao, W., De La Cruz, E.M., Yarema, K.J., & Braddock, D.T. (2020) Improving the pharmacodynamics and in vivo activity of ENPP1-Fc through protein and glycosylation engineering. Clinical and Translational Science, 14, 362-372 (doi: 10.1111/cts.12887Pubmed

Mertz, J.L., Sun, S., Yin, B., Betenbaugh, M.J., Yarema, K.J., & Zhang, H. (2020). Comparison of three glycoproteomics methods for the analysis of CHO cells treated with 1,3,4-O-Bu3ManNAc. Bioengineering7, article 144 (doi: 10.3390/bioengineering7040144Pubmed

Saeui, C.T., Cho, K.-c., Dharmarha, V., Nairn, A.V., Galizzi, M., Shah, S.R., Gowda, P., Park, M., Austin, M., Clarke, A., Cai, E., Buettner, M.J., Ariss, R., Moremen, K.W., Zhang, H., & Yarema, K.J. (2020) Cell line-, protein-, and sialoglycosite-specific control of flux-based sialylation in human breast cells: Implications for cancer progression. Frontiers in Chemistry 8, article 13 (doi: 10.3389/fchem.2020.00013)

Wang, Q., Chung, C.-Y., Yang, W., Yang, G., Chough, S., Chen, Y., Yin, B., Bhattachrarya, R., Hu, Y., Saeui, C.T., Yarema, K. J., Betenbaugh, M.J.& Zhang, H. (2019) Combining butyrated ManNAc with glycoengineered CHO cell improves EPO glycan quality and production. Biotechnology Journal14, article 1800186 (doi: 10.1002/biot.201800186Pubmed

Yin, B., Wang, Q., Chung, C.Y., Ren, X., Bhattacharya, R., Yarema, K.J., & Betenbaugh, M.J. (2018) Butryated ManNAc analog improves protein expression in Chinese hamster ovary cells. Biotechnology & Bioengineering, 115, 1531-1541 (doi: 10.1002/bit.26560) Pubmed

Saeui, C.T., Nairn, A.V., Galizzi, M., Douville, C., Gowda, P., Park, M., Dharmarha, V., Shah, S.R.,  Clarke, A., Austin, M., Moremen, K.W., & Yarema, K.J. (2018) Integration of genetic and metabolic features related to sialic acid metabolism distinguishes human breast cell subtypes. PLoS One, 13, e0195812 (doi: 10.1371/journal.pone.0195812) Pubmed

Meyer, R.A., Mathew, M.P., Ben-Akiva, E., Sunshine, J.C., Shmueli, R.B., Ren, Q., Yarema, K.J., & Green, J.J. (2018) Anistropic biodegradable lipid coated particles for spatially dynamic protein presentation. Acta Biomaterialia, 72, 228-238 (doi: 10.1016/j.actbio.2018.03.056) Pubmed

Song, Y., Kilburn, D., Song, J.H., Cheng, Y., Saeui, C.T., Cheung, D.G., Croce, C.M., Yarema,, K.J., Meltzer, S.J., Liu, K.J., & Wang, T.-H (2017) Determination of absolute expression profiles using multiplexed miRNA analysis. PLoS One, 12, e0180988 (doi:  10.1371/journal.pone.0180988) Pubmed

Kim, H., Shin, K., Park, O.K., Choi, D., Kim, H.D., Baik, S., Lee, S.H., Kwon, S.-H., Yarema, K.J., Hong, J., Hyeon, T., & Hwang, N.S.-Y. (2018) General and facile coating of single cells via mild reduction. Journal of the American Chemical Society, 140, 1199-1202 (doi: 10.1021/jacs.7b08440)

Saeui, C.T., Liu, L., Urias, E., Morrissette-McAlmon, J., Bhattacharya, R., & Yarema, K.J. (2017) Pharmacological, physiochemical, and drug-relevant biological properties of short chain fatty acid hexosamine analogues used in metabolic glycoengineering. Molecular Pharmaceutics, 15, 705-720 (doi: 10.1021/acs.molpharmaceut.7b00525) Pubmed

Yin, B., Wang, Q., Chung, C.-Y., Bhattacharya, R., Ren, X., Tang, J., Yarema, K.J., & Betenbaugh, M.J. (2017) A novel sugar analog enhances sialic acid production and biotherapeutic sialylation in CHO cells. Biotechnology & Bioengineering, 114, 1899-1902. (doi: 10.1002/bit.26291)

Song, Y., Kilburn, D., Song, J.H., Cheng, Y., Saeui, C.T., Cheung, D.G., Croce, C.M., Yarema, K.J., Meltzer, S.J., Liu, K.J. & Wang, T.-H. (2017) Determination of absolute expression profiles using multiplexed miRNA analysis. PLoS One, 12, e0180988 (doi: 10.1371/journal.pone.0180988) Pubmed

Mathew, M.P., Tan, E., Labonte, J.W., Shah, S., Saeui, C.T., Liu , L., Bhattacharya, R., Bovonratwet, P., Gray, J.J. & Yarema, K. (2017) Glycoengineering of esterase activity through metabolic flux-based modulation of sialic acid. ChemBioChem, 18, 1204-1215 (doi: 10.1002/cbic.201600698) Pubmed

Mathew, M.P., Tan, E., Saeui, C.T., Bovonratwet, P., Sklar, S., Bhattacharya, R. & Yarema, K.J. (2016) Metabolic flux-driven sialylation alters Internalization, recycling, and drug sensitivity of the epidermal growth factor receptor (EGFR) in SW1990 pancreatic cancer cells. Oncotarget, 7, 66491-66511 (doi: 10.18632/oncotarget.11582) Pubmed

Kim, C., Shores, L., Guo, Q., Aly, A., Jeon, O.H., Kim do, H., Bernstein, N., Bhattacharya, R., Chae, J.J., Yarema, K.J. & Elisseeff, J.H. (2016) Electrospun microfiber scaffolds with anti-inflammatory tributanoylated N-acetyl-D-glucosamine promote cartilage regeneration. Tissue Engineering Part A 22, 689-697 (doi: 10.1089/ten.tea.2015.0469) Pubmed

Kim, C., Jeon, O.H., Kim, D.H., Chae, J., Shores, L., Bernstein, N., Bhattacharya, R., Yarema, K.J. & Elisseeff., J.H.  (2016) Local delivery of a carbohydrate analog for reducing arthritic inflammation and rebuilding cartilage. Biomaterials.83:93-101. (doi: 10.1016/j.biomaterials.2015.12.029) Pubmed

Badr, H.A., AlSadek, D.M., Mathew, M.P., Li, C.Z., Djansugurova, L.B., Yarema, K.J. & Ahmed, H. (2015) Lectin staining and Western blot data showing differential sialylation of nutrient-deprived cancer cells to sialic acid supplementation. Data in Brief, 5,481-488 (doi: 10.1016/j.dib.2015.09.043) Pubmed

Badr, H.A., AlSadek, D.M.M., Mathew, M.P., Li, C.-Z., Djansugurova, L.B., Yarema, K.J., & Ahmed, H. (2015) Nutrient-deprived cancer cells preferentially use sialic acid to maintain cell surface glycosylation. Biomaterials, 70, 23-36 (doi: 10.1016/j.biomaterials.2015.08.020) Pubmed

Mishra, S., Bedja, D., Amuzie, C.A., Pomper, M.G., Bhattacharya, R., Yarema, K.J., & Chatterjee, S. (2015) Improved Intervention of atherosclerosis and cardiac hypertrophy through Biodegradable polymer-encapsulated delivery of glycosphingolipid inhibitor. Biomaterials, 64, 125-135 (doi: 10.1016/j.biomaterials.2015.06.001) Pubmed

Tian, Y., Almaraz, R. T., Chio, C., Li, Q. K., Li, D., Shad, P., Bhattacharya, R., Yarema, K. J., & Zhang, H. (2015) Identification of sialylated glycoproteins from metabolically oligosaccharide engineered pancreatic cells, Clinical Proteomics, 12, 11, eCollection 2015 (doi: 10.1186/s12014-015-9083-8) Pubmed

Mathew, M.P., Tan, E., Saeui, C.T., Bovonratwet, P., Liu, L., Bhattacharya, R., & Yarema, K.J. (2015) Metabolic glycoengineering sensitizes drug-resistant pancreatic cancer cells to tyrosine kinase inhibitors erlotinib and gefitinib. Bioorganic and Medicinal Chemistry Letters, 25, 1223-1227 (doi: 10.1016/j.bmcl.2015.01.060) Pubmed

Du, J., Tan, E., Kim, H.J., Zhang, A., Bhattacharya, R., & Yarema, K.J. (2014) Comparative evaluation of chitosan, cellulose acetate, and polyehersulfone nanofiber scaffolds for neural differentiation. Carbohydrate Polymers, 99, 483-490 (doi: 10.1016/j.carbpol.2013.08.050) Pubmed

Gibson, M., Li, H., Coburn, J., Moroni, L., Nahas, Z., Bingham 3rd, C., Yarema, K, & Elisseeff, J. (2014) Intra-articular delivery of glucosamine for treatment of experimental osteoarthritis created by a medial meniscectomy in a rat model. Journal of Orthopedic Research, 32, 302-309 (doi: 10.1002/jor.22445) Pubmed

Shah, P., Yang, S., Sun, S., Aiyetan, P., Yarema, K.J., & Zhang, H. (2013) Mass spectrometric analysis of sialylated glycans using solid phase labeling of sialic acids, Analytical Chemistry, 85, 3606-3613 (doi: 10.1021/ac3033867) Pubmed

Coburn, J.M., Bernstein, N., Bhattarcharya, R., Aich, U., Yarema, K.J., & Elisseeff, J.H. Differential response of chondrocytes and chondrogenic-induced mesenchymal stem cells to C1-OH tributanoylated N-acetylhexosamines, PLoS ONE, 8, e58899. (doi: 10.1371/journal.pone.0058899) Pubmed

Coburn, J. M., Wo, L., Berstein, N., Bhattacharya, R., Aich, U., Bingham III, C. O., Yarema, K. J., & Elisseeff, J. H. (2013) Short-chain fatty acid modified hexosamine analogs for tissue engineering osteoarthritic cartilage, Tissue Engineering, Part A, 19, 2035-2044 (doi: 10.1089/ten.tea.2012.0317) Pubmed

Bennun, S.V., Yarema, K.J., Betenbaugh, M.J., & Krambeck, F.J (2013) Integration of the transcriptome and glycome for identification of glycan cell signatures. PLoS Computational Biology, 9, e1002813 (doi: 10.1371/journal.pcbi.1002813) Pubmed

Mathew, M.P., Tan, E., Shah, S., Bhattacharya, R., Meledeo M.A., Huang, J., Espinoza, F.A., & Yarema, K.J., (2012) Extracellular and intracellular esterase processing of SCFA-hexosamine analogs: Implications for metabolic oligosaccharide engineering and drug delivery. Bioorganic and Medicinal Chemistry Letters, 22, 6929-6933 (doi: 10.1016/j.bmcl.2012.09.017) Pubmed

Almaraz, R.T., Tian, Y, Bhattarcharya, R., Tan, E., Chen, L., Zhang, Z., Zhang., H., Konstantopoulos, K., & Yarema, K.J. (2012) Metabolic flux increases sialylation: Implications for cell adhesion and cancer metastasis. Molecular & Cellular Proteomics. 11, M112.017558 (doi: 10.1074/mcp.M112.017558) Pubmed

Almaraz, R.T., Aich, U., Khanna, H.S., Tan, E., Bhattacharya, R., Shah, S. & Yarema, K.J. (2012) Metabolic oligosaccharide engineering with N-acyl functionalized ManNAc analogues: cytotoxicity, metabolic flux, and glycan-display considerations. Biotechnology & Bioengineering 109, 992-1006 (doi:10.1002/bit.24363 ) Pubmed

Du, J. Che, P.-L., Aich, U., Tan, E., Kim, H.J., Sampathkumar, S.-G., & Yarema, K.J. (2011)  Deciphering glycan linkages involved in Jurkat cell interactions with gold-coated nanofibers via sugar-displayed thiols. Bioorganic and Medicinal Chemistry Letters, 21, 4980-4984 (doi: 10.1016/j.bmcl.2011.05.044) Pubmed

von Bergen Granell, A.E., Palter, K.B., Aich, U., Yarema, K.J., Betenbaugh, M.J., Thornhill, W.B., & Recio-Pinto, E. (2011) Drosophila third instar larvae CNS neurons incorporate sialic acids. ACS Chemical Biology, 6, 1287-1295 (doi: 10.1021/cb200238k) Pubmed

Du, J., Che, P.-L., Wang, Z.-Y., Aich, U., Meledeo, M.A., & Yarema, K.J. (2011) Designing a binding interface for control of cancer cell adhesion via 3D topology and metabolic oligosaccharide engineering. Biomaterials, 32, 5427-5437 (doi: 10.1016/j.biomaterials.2011.04.005) Pubmed

Wang, Z.-Y., Che, P.-L., Ha, B., & Yarema, K.J. (2010) Static magnetic field exposure reproduces cellular effects of the Parkinson’s disease drug candidate ZM241385. PLoS ONE, 5, e13883 (doi: 10.1371/journal.pone.0013883) Pubmed

Lim, S.H., Liu, X.Y., Song, H., Yarema, K.J., & Mao, H.Q. (2010) The effect of nanofiber-guided cell alignment on the preferential differentiation of neural stem cells. Biomaterials, 31, 9031-9039 (doi: 10.1016/j.biomaterials.2010.08.021) Pubmed

Aich, U., Meledeo, M.A., Sampathkumar, S.G., Fu, J., Jones, M.B., Weier, C.A., Chung, S.Y., Tang, B.C., Yang, M., Hanes, J., & Yarema, K.J. (2010) Development of delivery methods for carbohydrate-based drugs: Controlled release of biologically-active short chain fatty acid-hexosamine analogs. Glycoconjugate Journal, 27, 445-459 (doi: 10.1007/s10719-010-9292-3) Pubmed

Krambeck, F.J., Bennun, S.V., Narang, S., Choi, S., Yarema, K.J., & Betenbaugh, M.J.  (2009) A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data. Glycobiology, 19, 1163-1175 (doi: 10.1093/glycob/cwp081) Pubmed

Elmouelhi, N., Aich, U., Paruchuri, V.D.P., Meledeo, M.A., Campbell, C.T., Wang, J.J., Srinivas, R., Khanna, H.S., & Yarema, K.J. (2009) The hexosamine template – A platform for modulating gene expression and for sugar-based drug discovery. Journal of Medicinal Chemistry, 52, 2515-2530 (doi: 10.1021/jm801661m) Pubmed

Wang, Z., Sarje, A., Che, P., & Yarema, K.J. (2009) Moderate strength (0.23-0.28 T) static magnetic fields (SMF) modulate signaling and differentiation in human embryonic cells. BMC Genomics, 10, article 356 (doi: 10.1186/1471-2164-10-356) Pubmed

Campbell, C.T., Aich, U., Weier, C.A, Wang, J.J., Choi, S.S., Wen, M.M., Maisel, K., Sampathkumar, S.-G., & Yarema, K.J.  (2008) Targeting pro-invasive oncogenes with short chain fatty acid-hexosamine analogs inhibits the mobility of metastatic MDA-MB-231 breast cancer cells. Journal of Medicinal Chemistry, 51, 8135-8147 (doi: 10.1021/jm800873k) Pubmed

Kim, E.J., Shin, H.Y., Park, S., Sung, D., Jon, S., Sampathkumar, S.G., Yarema, K.J., Choi, S.Y., & Kim, K.  (2008) Electrochemically active, anti-biofouling polymer adlayers on indium-tin-oxide electrodes. Chemical Communications, 14, 3543-3545 (doi: 10.1039/b804816a ) Pubmed

Daubeuf, S., Aucher, A., Sampathkumar, S.-G., Yarema, K.J. & Hudrisier, D. (2007) Chemical labels metabolically installed into the glycoconjugates of the target cell surface can be used to track lymphocyte/target cell interplay via trogocytosis. Comparisons with PKH and biotin. Immunological Investigations,36, 687-712 (doi: 10.1080/08820130701674596) Pubmed

Aich, U., Campbell, C.T., Weier, C., Wang, J., Sampathkumar, S.-G., & Yarema, K.J. (2008) Regioisomeric SCFA attachment to hexosamines separates metabolic flux from cytotoxicity and MUC1 suppression. ACS Chemical Biology, 3, 230-240 (doi: 10.1021/cb7002708) Pubmed

Varghese, S., Theprungsirikul, P., Sahani, S., Hwang, N., Yarema, K.J., & Elisseeff, J.H. (2007) Glucosamine modulates chondrocyte proliferation, matrix synthesis, and gene expression. Osteoarthritis Cartilage, 15, 59-68 (doi: 10.1016/j.joca.2006.06.008) Pubmed

Sampathkumar, S.-G., Jones, M.B., & Yarema, K.J. (2006) Metabolic expression of thiol-derivatized sialic acids on the cell surface and their quantitative estimation by flow cytometry. Nature Protocols, 1, 1840-1851 (doi: 10.1038/nprot.2006.252) Pubmed

Sampathkumar, S.-G., Li, A.V., & Yarema, K.J. (2006) Synthesis of non-natural ManNAc analogs for the expression of thiols on cell surface sialic acids. Nature Protocols,1, 2377-2385 (doi: 10.1038/nprot.2006.319) Pubmed

Sampathkumar, S.-G., Jones, M.B., Meledeo, M.A., Campbell, C.T., Choi, S.S., Hida, K.,  Gomutputra, P., Sheh, A., Gilmartin, T., Head, S. R., & Yarema, K.J. (2006) Targeting glycosylation pathways and the cell cycle: Sugar-dependent activity of butyrate-carbohydrate cancer prodrugs. Chemistry & Biology,13, 1265-1275 (doi: 10.1016/j.chembiol.2006.09.016) Pubmed

Wang, Z., Sun, Z., Li, A.V., & Yarema, K.J., (2006) Roles for GNE outside of sialic acid biosynthesis: modulation of sialyltransferase and BiP expression, GM3 and GD3 biosynthesis, proliferation and apoptosis, and ERK1/2 phosphorylation. Journal of Biological Chemistry, 281, 27016-27028 (doi: 10.1074/jbc.M604903200)

Faure, C., Chalazonitis, A., Rhéaume, C., Bouchard, G., Sampathkumar, S.-G., Yarema, K.J., & Gershon, M.D. (2007) Gangliogenesis in the enteric nervous system: roles of the polysialylation of the neural cell adhesion molecule and its regulation by Bone Morphogenetic Protein-4. Developmental Dynamics; 236, 44-59 (doi: 10.1002/dvdy.20943) Pubmed

Sampathkumar, S.-G., Li, A., Jones, M.B.,& Yarema, K.J. (2006)Metabolic installation of thiols into sialic acid modulates adhesion and stem cell biology. Nature Chemical Biology,2, 149-152 (doi: 10.1038/nchembio770) Pubmed

Salama, I., Hinderlich, S., Shlomai, Z., Eisenberg, I., Krause, S., Yarema, K., Argov, Z., Lochmuller, H., Reutter, W., Dabby, R., Sadeh, M., Ben-Bassat, H.,&  Mitrani-Rosenbaum, S., (2005) No overall hyposialylation in hereditary inclusion body myopathy myoblasts carrying the homozygous M712T GNE mutation. Biochemical and Biophysical Research Communications, 328, 221-226 (doi: 10.1016/j.bbrc.2004.12.157 ) Pubmed

Hinderlich, S., Salama, I., Eisenberg, I., Potikha, T., Manteya, L., Yarema, K.J., Horstkorte, R., Argov, A., Sadeh, M., Reutter, W., & Mitrani-Rosenbaum, S. (2004) The homozygous M712T mutant of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase results in reduced enzyme activities but not in altered overall cellular sialylation in hereditary inclusion body myopathy.  FEBS Letters, 566, 105-109 (doi: 10.1016/j.febslet.2004.04.013)

Kim, E.J., Jones, M.B., Rhee, J.K., Sampathkumar, S.-G., & Yarema, K.J. (2004) Establishment of ManNAc analog-resistant cell lines as improved hosts for sialic acid engineering applications. Biotechnology Progress, 20, 1674-1682 (doi: 10.1021/bp049841q)

Kim, E.J., Sampathkumar, S.G., Jones, M.B., Rhee, J.K., Baskaran, G., Goon, S., & Yarema, K.J. (2004) Characterization of the metabolic flux and apoptotic effects of O-hydroxyl- and N-acyl-modifed N-acetylmannosamine (ManNAc) analogs in Jurkat (human T-lymphoma-derived) cells. Journal of Biological Chemistry, 279, 18342-18352 (doi: 10.1074/jbc.M400205200) Pubmed

Jones, M.B., Teng, H., Rhee, J.K., Baskaran, G., Lahar, N., & Yarema, K.J., (2004) Characterization of the cellular uptake and metabolic conversion of acetylated N-acetylmannosamine (ManNAc) analogs to sialic acids.  Biotechnology & Bioengineering, 85, 394-405 (doi: 10.1002/bit.10901) Pubmed

Viswanathan, K., Lawrence, S., Hinderlich, S., Yarema, K.J., Lee, Y.C, & Betenbaugh, M.J. (2003) Engineering the sialic acid synthetic activity into insect cells: Identifying metabolic bottlenecks and devising strategies to overcome them. Biochemistry 42, 15215-15225 (doi: 10.1021/bi034994s) Pubmed

Luchansky, S.J., Yarema, K.J., Takahashi, S., & Bertozzi, C.R. (2003) GlcNAc 2-epimerase can serve a catabolic role in sialic acid metabolism. Journal of Biological Chemistry, 278, 8035-8042 (doi: 10.1074/jbc.M212127200) Pubmed

Jacobs, C.L., Goon, S., Yarema, K.J., Hinderlich, S., Hang, H.C., Chai, D.H., & Bertozzi, C.R. (2001) Substrate specificity of the sialic acid biosynthetic pathway.  Biochemistry, 40, 12864-12874 (doi: 10.1021/bi010862s) Pubmed

Yarema, K.J., Goon, S., & Bertozzi, C.R. (2001) Metabolic selection of glycosylation defects in human cells.  Nature Biotechnology, 19, 553-558 (doi: 10.1038/89305) Pubmed

Lemieux, G.A., Yarema, K.J., Jacobs, C.L., & Bertozzi, C.R. (1999) Exploiting differences in sialoside expression for selective targeting of MRI contrast reagents.  Journal of the American Chemical Society, 121, 4278-4279 (doi: 10.1021/ja984228m)

Yarema, K.J., Mahal, L.K., Bruehl, R.E. Rodriguez, E.C., & Bertozzi, C.R. (1998)  Metabolic delivery of ketone groups to sialic acid residues.  Application to cell surface engineering.  Journal of Biological Chemistry, 273, 31168-31179 (doi:10.1074/jbc.273.47.31168) Pubmed

Mahal, L.K., Yarema, K.J., & Bertozzi, C.R. (1997) Engineering chemical reactivity on cell surfaces through oligosaccharide biosynthesis. Science276, 1125-1128 (doi: 10.1126/science.276.5315.1125) Pubmed

Rink, S.M., Yarema, K.J., Solomon, M.S., Paige, L.A., Tadayoni, M., Essigmann, J.M., & Croy, R.G. (1996) Synthesis and biological activity of DNA damaging agents that form decoy binding sites for the estrogen receptor.  Proceedings of the National Academy of Science, U.S.A., 93, 15063-15068 (doi: 10.1073/pnas.93.26.15063) Pubmed

Moggs, J.G., Yarema, K.J., Essigmann, J.M., & Wood., R.D. (1996) Analysis of incision sites produced by human cell extracts and purified proteins during nucleotide excision repair of a 1,3-intrastrand d(GpTpG)-cisplatin adduct. Journal of Biological Chemistry, 271, 7177-7186 (doi: 10.1074/jbc.271.12.7177) Pubmed

Yarema, K.J., Lippard, S.J., & Essigmann, J.M. (1995) Mutagenic and genotoxic effects of DNA adducts formed by the anticancer drug cis-diamminedichloroplatinum(II).  Nucleic Acids Research,23, 4066-4072 (doi: 10.1093/nar/23.20.4066) Pubmed

Yarema, K.J., Wilson, J.M., Lippard, S.J., & Essigmann, J.M. (1994) Effects of DNA adduct structure and distribution on the mutagenicity and genotoxicity of two platinum anticancer drugs. Journal of Molecular Biology, 236, 1034-1048 (doi: 10.1016/0022-2836(94)90010-8) Pubmed

Bradley, L.J.N., Yarema, K.J., Lippard, S.J., & Essigmann, J.M. (1993) Mutagenicity and genotoxicity of the major DNA adduct of the antitumor drug cis-diamminedichloroplatinum(II).  Biochemistry, 32, 982-988 (doi: 10.1021/bi00054a031) Pubmed

Szymkowski, D.E., Yarema, K., Lippard, S.J., Essigmann, J.M., & Wood, R.D. (1992) An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts.  Proceedings of theNational Academy of Science, U.S.A., 89, 10772-10776 (doi: 10.1073/pnas.89.22.10772) Pubmed

Kouchakdjian, M., Eisenberg, M., Yarema, K., Basu, A., Essigmann, J., & Patel, D.J.  (1991) NMR studies of the exocyclic 1,N6-ethenodeoxyadenosine adduct (edA) opposite thymidine in a DNA duplex. Nonplanar alignment of edA(anti) and dT(anti) at the lesion site.  Biochemistry, 30, 1820-1828 (doi: 10.1021/bi00221a014) Pubmed

de los Santos, C., Kouchakdjian, M., Yarema, K., Basu, A., Essigmann, J., & Patel, D.J. (1991) NMR studies of the exocyclic 1,N6-ethenodeoxyadenosine adduct (edA) opposite thymidine in a DNA duplex. edA(syn)-dG(anti) pairing at the lesion site. Biochemistry, 30, 1828-1835 (doi: 10.1021/bi00221a015) Pubmed