Recent Research Publications
Ludwig, S.D., Bernstein, A.J., Agatemor, C., Dammen-Brower, K., Ruffolo, J., Rosas, J.M., Post, J.D., Cole, R.N., Yarema, K.J., & Spangler, J.B. (2022) A versatile design platform for glycoengineering therapeutic antibodies. mAbs, 14, article 2095704 (doi: 10.1080/19420862.2022.2095604)
Du., J., Liu, X.,, Yarema, K.J., & Jia. X. (2022) Glycoengineering human neural stem cells (hNSCs) for adhesion improvement using a novel thiol-modified N-acetylmannosamine (ManNAc) analog. Biomaterials Advances, 134, article 112675 (doi: 10.1016/j.msec.2022.112675) Pubmed
Du, J., Agatemor, C., Saeui, C., Bhattacharya, R., Jia, X., & Yarema, K.J. (2021) Glycoengineering human neural and adipose stem cells with novel thiol-modified N-acetylmannosamine (ManNAc) analogs. Cells, 10, article 377 (doi: 10.3390/cells10020377) Pubmed
Stabach, P.R., Zimmerman, K., Adame, A., Kavanagh, D., Saeui, C.T., Agatemor, C., Gray, S., Cao, W., De La Cruz, E.M., Yarema, K.J., & Braddock, D.T. (2020) Improving the pharmacodynamics and in vivo activity of ENPP1-Fc through protein and glycosylation engineering. Clinical and Translational Science, 14, 362-372 (doi: 10.1111/cts.12887) Pubmed
Mertz, J.L., Sun, S., Yin, B., Betenbaugh, M.J., Yarema, K.J., & Zhang, H. (2020). Comparison of three glycoproteomics methods for the analysis of CHO cells treated with 1,3,4-O-Bu3ManNAc. Bioengineering, 7, article 144 (doi: 10.3390/bioengineering7040144) Pubmed
Saeui, C.T., Cho, K.-c., Dharmarha, V., Nairn, A.V., Galizzi, M., Shah, S.R., Gowda, P., Park, M., Austin, M., Clarke, A., Cai, E., Buettner, M.J., Ariss, R., Moremen, K.W., Zhang, H., & Yarema, K.J. (2020) Cell line-, protein-, and sialoglycosite-specific control of flux-based sialylation in human breast cells: Implications for cancer progression. Frontiers in Chemistry 8, article 13 (doi: 10.3389/fchem.2020.00013)
Wang, Q., Chung, C.-Y., Yang, W., Yang, G., Chough, S., Chen, Y., Yin, B., Bhattachrarya, R., Hu, Y., Saeui, C.T., Yarema, K. J., Betenbaugh, M.J.& Zhang, H. (2019) Combining butyrated ManNAc with glycoengineered CHO cell improves EPO glycan quality and production. Biotechnology Journal. 14, article 1800186 (doi: 10.1002/biot.201800186) Pubmed
Full list of research publications
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Recent Review Articles
Dammen-Brower, K. Epler, P., Zhu, S., Bernstein, Z.J., Stabach, P.R., Braddock, D.T., Spangler, J.B. & Yarema, K.J. (2022) Strategies for glycoengineering therapeutic proteins. Frontiers in Chemistry, 10, article 863118 (doi: 10.3389/fchem.2022.863118)
Agatemor, C., Buettner, M.J., Ariss, R., Muthiah, K., Saeui, C.T., & Yarema, K.J. (2019) Exploiting metabolic glycoengineering to advance healthcare. Nature Reviews Chemistry, 3, 605-620 (doi: 10.1038/s41570-019-0126-y) Pubmed
Buettner, M.J., Shah, S.R., Saeui, C.T., Ariss, R., & Yarema, K.J. (2018) Improving immunotherapy through glycodesign. Frontiers in Immunology, 9, article 2485 (doi: 10.3389/fimmu.2018.02485) Pubmed
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Recent Book Chapters
Agatemor, C., Muthiah, K., Ha, L., Jukes, M., Chai, J., Osman, A., Robertson, B., & Yarema, K.J. (2021) Imaging glycans with metabolic glycoengineering. Comprehensive Glycoscience, 2nd Edition. Elsevier, 253-274 (doi: 10.1016/B978-0-12-409547-2.14962-5)
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Recent Patents
Yarema, K.J., CT Saeui, C.T., Quinones-Hinojosa, A., & Shah, S.R. Use of UAP inhibitors to inhibit flux through the hexosamine biosynthetic pathway US Patent App. 17/127,979, 2021
Yarema, K.J., Aich, U., & Almaraz, R.T. Use of high flux SCFA-derivatized monosaccharides in recombinant glycoprotein production US Patent 11,015,215, 2021
Elisseeff, J.H., Yarema, K., Coburn, J., & Aich, U. Short-chain fatty acid hexosamine analogs and their use in tissue engineering applications US Patent 10,227,369, 2019
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